Fatty acid activation in carcinogenesis and cancer development: Essential roles of long‑chain acyl‑CoA synthetases (Review)
![The primary mechanism of ferroptosis. ACSL4 acylates PUFA, which is... | Download Scientific Diagram The primary mechanism of ferroptosis. ACSL4 acylates PUFA, which is... | Download Scientific Diagram](https://www.researchgate.net/publication/351089069/figure/fig1/AS:11431281081192559@1661565634941/The-primary-mechanism-of-ferroptosis-ACSL4-acylates-PUFA-which-is-then-esterified-by.png)
The primary mechanism of ferroptosis. ACSL4 acylates PUFA, which is... | Download Scientific Diagram
![Seco-Lupane Triterpene Derivatives Induce Ferroptosis through GPX4/ACSL4 Axis and Target Cyclin D1 to Block the Cell Cycle | Journal of Medicinal Chemistry Seco-Lupane Triterpene Derivatives Induce Ferroptosis through GPX4/ACSL4 Axis and Target Cyclin D1 to Block the Cell Cycle | Journal of Medicinal Chemistry](https://pubs.acs.org/cms/10.1021/acs.jmedchem.2c00664/asset/images/large/jm2c00664_0021.jpeg)
Seco-Lupane Triterpene Derivatives Induce Ferroptosis through GPX4/ACSL4 Axis and Target Cyclin D1 to Block the Cell Cycle | Journal of Medicinal Chemistry
![Mechanism of ferroptosis. ACSL4 and LPCAT3 enzymes are required for the... | Download Scientific Diagram Mechanism of ferroptosis. ACSL4 and LPCAT3 enzymes are required for the... | Download Scientific Diagram](https://www.researchgate.net/publication/369284018/figure/fig2/AS:11431281127208543@1678979221472/Mechanism-of-ferroptosis-ACSL4-and-LPCAT3-enzymes-are-required-for-the-initiation-of.png)
Mechanism of ferroptosis. ACSL4 and LPCAT3 enzymes are required for the... | Download Scientific Diagram
![ACSL4 deficiency confers protection against ferroptosis-mediated acute kidney injury - ScienceDirect ACSL4 deficiency confers protection against ferroptosis-mediated acute kidney injury - ScienceDirect](https://ars.els-cdn.com/content/image/1-s2.0-S2213231722000349-ga1.jpg)
ACSL4 deficiency confers protection against ferroptosis-mediated acute kidney injury - ScienceDirect
Functional Interaction between Acyl-CoA Synthetase 4, Lipooxygenases and Cyclooxygenase-2 in the Aggressive Phenotype of Breast Cancer Cells | PLOS ONE
![Activation of ALOX12 by a multi-organelle-orienting photosensitizer drives ACSL4-independent cell ferroptosis | Cell Death & Disease Activation of ALOX12 by a multi-organelle-orienting photosensitizer drives ACSL4-independent cell ferroptosis | Cell Death & Disease](https://media.springernature.com/full/springer-static/image/art%3A10.1038%2Fs41419-022-05462-9/MediaObjects/41419_2022_5462_Figa_HTML.png)
Activation of ALOX12 by a multi-organelle-orienting photosensitizer drives ACSL4-independent cell ferroptosis | Cell Death & Disease
![Frontiers | Inhibition of Acyl-CoA Synthetase Long-Chain Family Member 4 Facilitates Neurological Recovery After Stroke by Regulation Ferroptosis Frontiers | Inhibition of Acyl-CoA Synthetase Long-Chain Family Member 4 Facilitates Neurological Recovery After Stroke by Regulation Ferroptosis](https://www.frontiersin.org/files/Articles/632354/fncel-15-632354-HTML/image_m/fncel-15-632354-g007.jpg)
Frontiers | Inhibition of Acyl-CoA Synthetase Long-Chain Family Member 4 Facilitates Neurological Recovery After Stroke by Regulation Ferroptosis
![Model of ferroptosis and key molecules in the adrenal cortex. ACSL4... | Download Scientific Diagram Model of ferroptosis and key molecules in the adrenal cortex. ACSL4... | Download Scientific Diagram](https://www.researchgate.net/publication/339994050/figure/fig3/AS:870280117366787@1584502357253/Model-of-ferroptosis-and-key-molecules-in-the-adrenal-cortex-ACSL4-catalyzes-activation.png)
Model of ferroptosis and key molecules in the adrenal cortex. ACSL4... | Download Scientific Diagram
Fatty acid oxidation protects cancer cells from apoptosis by increasing mitochondrial membrane lipids
The positive feedback between ACSL4 expression and O-GlcNAcylation contributes to the growth and survival of hepatocellular carcinoma | Aging
![Frontiers | ACSL4 as a Potential Target and Biomarker for Anticancer: From Molecular Mechanisms to Clinical Therapeutics Frontiers | ACSL4 as a Potential Target and Biomarker for Anticancer: From Molecular Mechanisms to Clinical Therapeutics](https://www.frontiersin.org/files/Articles/949863/fphar-13-949863-HTML/image_m/fphar-13-949863-g001.jpg)
Frontiers | ACSL4 as a Potential Target and Biomarker for Anticancer: From Molecular Mechanisms to Clinical Therapeutics
![ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition. - Abstract - Europe PMC ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition. - Abstract - Europe PMC](https://europepmc.org/articles/PMC5610546/bin/nihms876501u1.jpg)
ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition. - Abstract - Europe PMC
![Acyl-CoA synthetase-4 is implicated in drug resistance in breast cancer cell lines involving the regulation of energy-dependent transporter expression - ScienceDirect Acyl-CoA synthetase-4 is implicated in drug resistance in breast cancer cell lines involving the regulation of energy-dependent transporter expression - ScienceDirect](https://ars.els-cdn.com/content/image/1-s2.0-S000629521830474X-ga1.jpg)
Acyl-CoA synthetase-4 is implicated in drug resistance in breast cancer cell lines involving the regulation of energy-dependent transporter expression - ScienceDirect
![Identification of p115 as a novel ACSL4 interacting protein and its role in regulating ACSL4 degradation - ScienceDirect Identification of p115 as a novel ACSL4 interacting protein and its role in regulating ACSL4 degradation - ScienceDirect](https://ars.els-cdn.com/content/image/1-s2.0-S1874391920302943-ga1.jpg)
Identification of p115 as a novel ACSL4 interacting protein and its role in regulating ACSL4 degradation - ScienceDirect
Seco-Lupane Triterpene Derivatives Induce Ferroptosis through GPX4/ACSL4 Axis and Target Cyclin D1 to Block the Cell Cycle | Journal of Medicinal Chemistry
![IJMS | Free Full-Text | ACSL4-Mediated Ferroptosis and Its Potential Role in Central Nervous System Diseases and Injuries IJMS | Free Full-Text | ACSL4-Mediated Ferroptosis and Its Potential Role in Central Nervous System Diseases and Injuries](https://www.mdpi.com/ijms/ijms-24-10021/article_deploy/html/images/ijms-24-10021-g001.png)
IJMS | Free Full-Text | ACSL4-Mediated Ferroptosis and Its Potential Role in Central Nervous System Diseases and Injuries
![AIM2 promotes renal cell carcinoma progression and sunitinib resistance through FOXO3a-ACSL4 axis-regulated ferroptosis [Abstract] AIM2 promotes renal cell carcinoma progression and sunitinib resistance through FOXO3a-ACSL4 axis-regulated ferroptosis [Abstract]](https://www.ijbs.com/v19/p1266/toc.jpg)